Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-17A (IL-17A), and provides an IL-17A

Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial Spondyloarthritis (axSpA).

Affibody: ClinicalTrials.gov Identifier: NCT03591887 Other Study ID Numbers: ABY-035-002 2017-001615-36 ( EudraCT Number ) First Posted: July 19, 2018 Key Record Dates: Last Update Posted: July 10, 2020 Last Verified: July 2020 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Affibody secures production capacity for ABY-035. An important next step in the advancement of ABY-035 to late stage clinical development. “Ensuring large scale high quality production of our ABY-035 drug is a natural next step in our evolution as a company with the ambition to have development, manufacturing, and commercialization expertise”, said David Bejker, CEO of Affibody. Partners will continue to file INDs in additional applications in autoimmune diseases during 2021. SAN DIEGO, CA, USA; SHANGHAI, China, and SOLNA, Sweden I March 9, 2021 I Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed to Phase 2 clinical Affibody announces that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program. “This Affibody molecule, ABY-035, has been specifically designed to capture the unique aspects of the Affibody technology.

It is a bivalent heterodimer, comprising two linked affibodies that bind two different IL-17 epitopes. That construct is coupled to a third component, Albumod, Affibody’s small albumin-binding domain, which extends the molecule’s half-life. “ABY-035 is a unique multivalent and bispecific molecule, targeting both subunits of IL-17 as well as albumin and the Phase 2 AFFIRM-35 study is designed to take full advantage of the strengths of the dual targeting ABY-035. Affibody, a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”).

Initial results confirm compound to be safe and well-tolerated across all doses in healthy volunteers. Affibody: ClinicalTrials.gov Identifier: NCT04706741 Other Study ID Numbers: ABY-035-203 : First Posted: January 13, 2021 Key Record Dates: Last Update Posted: January 19, 2021 Last Verified: December 2020 Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in Affibody: ClinicalTrials.gov Identifier: NCT03591887 Other Study ID Numbers: ABY-035-002 2017-001615-36 ( EudraCT Number ) First Posted: July 19, 2018 Key Record Dates: Last Update Posted: July 10, 2020 Last Verified: July 2020 Individual Participant … Affibody AB (“Affibody”) today announced that it has completed the dose-escalation part of a Phase I study of ABY-035, which is the company’s proprietary psoriasis program. Initial results confirm compound to be safe and well-tolerated across all doses in healthy volunteers.

Solna, Sweden, July 16, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of the planned 12 week interim analysis in the Company’s Phase 2 proof-of-concept study of its bispecific molecule ABY-035 for moderate-to-severe psoriasis (“AFFIRM-35”).

2010-06-18 · Affibody molecules can also block soluble protein ligands as exemplified with a TNFα specific Affibody molecule that could block binding of the TNF ligand to the TNF-receptor , in in vitro studies. An interesting case is an Affibody molecule specific for the amyloid-β (Aβ) peptide involved in Alzheimer’s disease [72] .

ABY-035 has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong (KD ~50pM) binding affinity to serum albumin.

ABY-035 acts by blocking interleukin IL-17A. IL-17A is thought to Mar 20, 2021 PDF | Affibody molecules can be used as tools for molecular recognition in and the molecule was named ABY-035 and has entered clinical.

ABY-035 is a novel bispecific agent, potently targeting both subunits of IL-17A as well as albumin, which has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”). Affibody Announces Interim Analysis in Phase 2 Psoriasis Trial of ABY-035 ons, jul 17, 2019 09:16 CET. Solna, Sweden, July 16, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of the planned 12 week interim analysis in the Company’s Phase 2 proof-of-concept study of its bispecific Affibody Announces Interim Analysis in Phase 2 Psoriasis Trial of ABY-035 Pressmeddelande • Jul 16, 2019 16:00 CEST Solna, Sweden, July 16, 2019. 2021-03-09. Affibody and Inmagene announce IND Clearance for izokibep (ABY-035) for the treatment of Non-infectious Non-anterior Uveitis. San Diego, U.S., Shanghai, China, and Solna, Sweden, March 9, 2021.
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ABY-035 acts by blocking interleukin IL-17A.
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Feb 15, 2021 “Working closely with our partner Affibody, the Inmagene team is Also called IMG-020 andABY-035, izokibep is an engineered protein.

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HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein. A novel affibody-based construct, ZHER2:2891-ABD035-DOTA (ABY-027), was

Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of enrollment in the Company’s Phase 2 proof-of-concept study of ABY-035 for moderate-to-severe psoriasis (“AFFIRM-35”). Affibody Announces Initial Results from a Phase I Study of ABY-035 Solna, Sweden, May 4, 2016. Affibody AB (“Affibody”) today announced that it has completed the dose-escalation part of a Phase I study of ABY-035, which is the company’s proprietary psoriasis program. Affibody and Inmagene Biopharmaceuticals has announced that the FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial Spondyloarthritis (axSpA). Affibody: ClinicalTrials.gov Identifier: NCT03580278 Other Study ID Numbers: ABY-035-101 : First Posted: July 9, 2018 Key Record Dates: Last Update Posted: November 30, 2020 Last Verified: November 2020 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No 2021-03-10 2017-03-24 2020-04-01 2010-06-18 Affibody molecules can be engineered in different formats. (a) and the molecule wa s named ABY-035 and ha s entered clinic al. developmen t.